Causes of Pilocytic astrocytoma

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Pilocytic astrocytoma may be related to the genetic condition neurofibromatosis kind 1 (NF1), and optic gliomas are a number of the maximum regularly encountered tumors in patients with this disorder. The majority of pilocytic astrocytomas, but, arise sporadically - with no proof of a link to an underlying hereditary predisposition or life-style element. They are associated with genetic changes inside the MAPK/ERK pathway, maximum frequently a characteristic KIAA1549-BRAF fusion gene.

Leiomyosarcoma (LMS) - Cancer

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Leiomyosarcoma is a dangerous (malignant) smooth muscle growth. A harmless growth beginning from a similar tissue is named leiomyoma. While leiomyosarcomas are not idea to emerge from leiomyomas, some leiomyoma variations' order is developing.

How does the Rhabdomyosarcoma (RMS) describe in Children/Adolescence/Youth/Childhood ?

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Rhabdomyosarcoma is for the most part viewed as an infection of youth, as by far most of cases happen in those beneath the age of 18. It is regularly portrayed as one of the little blue-round-cell cancers of adolescence because of its appearance on a H&E stain. Despite being moderately uncommon, it represents roughly 40% of all recorded delicate tissue sarcomas.

MALIGNANT FIBROUS HISTIOCYTOMA - CANCER

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MALIGNANT FIBROUS HISTIOCYTOMA, also known as UNDIFFERENTIATED PLEOMORPHIC SARCOMA, can be defined as soft-tissue sarcoma. 

Malignant Fibrous Histiocytoma is indicated a diagnoses of exclusion for sarcomas that cannot be more preciously classified or defined. Other sarcomas are cancer in the form of bone and soft-tissues, involving muscles, fat, blood-vessels and lymph vessels and fibrous tissues i.e., tendons and ligaments.

CHONDROSARCOMA - BONE AND MUSCLE SARCOMA

CHONDROSARCOMA, can be defined as bone sarcoma, a primary cancer comprises of cells derived from transformed cells that produce cartilage. 

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A Chondrosarcoma is a member of a category of tumors of bone and soft tissues known as sarcomas. 

Approximately, 30% of bone sarcomas are Chondrosarcoma. It is resistant to chemotherapy and radiotherapy. Unlike, other primary bone sarcomas that mainly adversely influenced children and adolescence, a Chondrosarcoma can be present in any age. It is more frequently adversely influenced the axial skeleton than the appendicular skeleton. 

TYPES OF CANCER

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• BONE AND MUSCLE SARCOMA CANCER

• BRAIN AND NERVOUS SYSTEM CANCER

• BREAST CANCER

• ENDOCRINE SYSTEM CANCER

• EYE CANCER

• GASTROINTESTINAL CANCER 

• GENITOURINARY AND GYNECOLOGIC CANCER

•  HEAD AND NECK CANCER

• HEMATOPOIETIC CANCER

• SKIN CANCER

• THORACIC AND RESPIRATORY CANCER

• HIV/AIDS CANCER

CAUSES OF CANCER

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Tobacco is the major cause and reason of Cancer. Approximately, 22% of death caused by Tobacco. About 10% are coz of obesity, poor-diet, lack of physical activity, excessive intake of alcohol, substance-use or addiction. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are coz of infections such as Helicobacter pylori, hepatitis-B, hepatitis-C, human papillomavirus infection, Epstein-Barr virus and human immunodeficiency virus (HIV).

Approximately, 5% - 10% of cancers are due to inherits genetic defects. Cancer can be detected by certain Signs and Symptoms or screening tests. It is then typically further investigated by medical imaging, and confirmed by biopsy.

TYPES OF HEART DISEASES

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• CORONARY ARTERY DISEASE (CAD)

• HEART ARRHYTHMIAS

• HEART FAILURE

• HEART VALVE DISEASE

• PERICARDIAL DISEASE

• CARDIOMYOPATHY (HEART MUSCLE DISEASE)

• CONGENTIAL HEART DISEASE 

• PULMONARY STENOSIS

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Self-Isolation against COVID-19

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SELF-ISOLATION, can be defined as protecting ourselves by sitting at home. It has been recommended and suggested after observed, judged and diagnosed the symptoms of the pandemic - COVID-19 (Corona-Virus). Health agencies have also issued and suggested the elaborated list for proper and hygienic self-isolation. 

World-Wide's Government have made it mandatory self-quarantine, lock-down and social distancing for the whole population globally. The strongest and highly recommended instructions have been issued to those high-risk cluster. The person who is recently exposed to COVID-19 while traveling from one country to another on airport have been made mandatory and advised for self-quarantine for 14 days at least, coz of there are chances of wide-spread transmission and increasing of COVID-19 infected patients.

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Signs and symptoms of Spanish Flu

 

The majority of the affected experience only the typical flu symptoms of sore throat, headache and fewer, especially during the first case. However, during the second case, disease was more serious, often complicated by bacterial pneumonia, which was often the cause of death. This more serious type could cause hellotrope cycanosis to develop whereby the skin would first develop two mahogany spots over the cheekbones which would then over the few hours spread to color the entire face blue followed by black coloration first in the extremities and then further spreading to the limbs and torso. After this, death would follow within a hours or few days coz of lungs would filled with fluid. Other signs and symptoms reporting included spontaneous mouth and nosebleeds, miscarriages for pregnant women, a peculiar smell, teeth, hair falling, dizziness, insomnia, loss of hearing and smell, blurred vision, impaired color vision.

The majority of deaths were from bacterial pneumonia, a common secondary symptoms associated with influenza. The pneumonia by itself caused common upper respiratory-tract bacteria, which were able to get into the lungs via the damaged bronchial tubes of the victims. The virus also killed the people directly by causing massive hemorrhages and edema in the lungs. Modern analysis shows the virus is particularly deadly coz it triggers a cytokine storms (overreaction of the body's immune system). The animal suffered rapidly progressive respiratory system and death through the cytokine storm. The strong immune systems of young adults were postulated to have ravaged the body, whereas the weaker immune reaction of children and middle-aged young adults resulted in fewer deaths in those groups.

FIRST WAVE - Spanish Flu

The pandemic is conventionally marked as having begun on 4th march, 1918. The first wave of the Flu lasted from the first quarter of 1918 was relatively mild. Morality rates were not appreciably above normal; in the United States ~75,000 flu-related deaths were reported in the first six months of 1918 as compared to ~63,000 deaths during the same period in 1915. In Madrid, Spain fewer than 1,000 people died from influenza between May and June 1918. There were no reported quarantines during the first quarter of 1918. However the first wave spread a significant disruption in the military operation of World War 1, with three quarters of French troops, half the British forces, and over 9,00,000 German soldiers sick. 

.......we'll discuss 2nd wave of spanich Flu in next article

SPANISH FLU

In 1918, a pandemic which affected the people worldwide, a Spanish Flu, also known as the Great influenza epidemic or 1918 influenza pandemic, was exceptionally deadly life-threatening universally influenza pandemic caused by H1N1 influenza virus. The premature cases was found in France, Germany and United kingdom in April. After 2 years, approximately, two-third of population around 500 million world-wide infected, was infected in four successive waves.

Description of Spanish Flu :

Most influenza outbreaks disproportionately kill the young and old, with higher survival rates in between, but this pandemic had unusually high morality among young adults. The virus was particularly deadly coz it triggered a cytokine storm, ravaging the stronger immune system of young adults; although the virus infection was apparently no more aggressive than previously influenza strains. Malnourishment, over_crowded medical camps and hospitals, and poor hygiene, promoted bacterial superinfection, killing most of the victims after a typically prolonged death bed.

In 1918, Spanich Flu, was the first of three flu pandemics caused by H1N1 influenza A virus; the most recent one is COVID-19, Corona virus spread by virus. In 1977, the Russian Flu was also spread by H1N1 virus, but it mostly affected the younger population.

...... in next article, we'll continue with this topic... 😝 😜

BLACK DEATH

In human history, there have been number of pandemics of diseases such as small-pox; the most deadly, tragic and incurable pandemic experienced in history/ancient time, was the "Black death" (was known for plaque), which was killed 75-200 million people worldwide in 14th century. It was caused by the bacterium yersinia pesttis and may also caused by septicaemic or pneumonia plaques. 

It was the origination of the second plaque pandemic. The plaque spread social, religious and economic upheavals, with increasing and expanding influence on the course of European history. This pandemic originated either in Central-Asia or East-Asia, but it's first appearance was seen in Crimea in 1347; it was most likely carried by fleas living on the black rats on Genoese slave ships spreading through Mediterranean Basin reaching Africa, Western-Asia and the rest of Europe via.

The black death was the most great natural disaster to strike Europe during the late middle ages (the first was being the Great Famine of 1315-1317) and is estimated to have killed approximately 30 percent to 60 percent of European population. The plaque also might have reduced the World's population approximately 475 million to 350-375 million in the 14th century.

Description/Explanation of Black death/Plaque :

It was identified and sanctioned that an epidemiological account of plaque is as predominant as an recognization of symptoms, but researchers are hampered by the lack of reliable statistics from the period. Archaeologist Barney Sloane argued that there is insufficient evidences and proofs of the extinction of numerous rats in the Archaeological records of the medieval waterfront in London and the disease spread too quickly to support the thesis that Y. Pestis was spread from fleas on rats; he argued that transmission must have been from person to person.  This theory is reported by research in 2018 which suggested transmission was more likely by body lice and fleas during the second plaque pandemic.

SUMMARY :

With past experience & evidences, intellectual discussion and argumentation, no single evidences has achieved any solution; World-Wide accepted.

......At the end, Finally & Eventually, "Plaque is plaque." 😉 😜 😜

Most common types of diseases

 There are 10 most common types of diseases :

• HEART DISEASE

• CANCER DEATHS

• UNINTENTIAL INJURIES

• CHRONIC LOWER RESPIRATORY DISEASE

• STROKE ABOUT CEREBROVASCULAR DISAESES

• ALZHEIMER'S DESEASE

• DIABETES

• INFLUENZA AND PNEUMONIA

• KIDNEY DISEASE

• SUICIDE

.....in further articles we'll discuss in details... 😋 😋😋 

What is disease ?

DESCRIPTION OF DISEASE :

Disease, is a specific or definite anomalous state i.e., adversely and weakly influence the frame, physical structure and functioning of all or part of organism which is not coz of instant superficial damage. 

Disease are frequently called dysfunction that are associated with particular manifestation.

A disease can be spread by exotic such as bacillus or other internal disorder. For example - internal disorder of immune system can produce a variety of diseases includes acquired immunodeficiency syndrome, allergies, hyper acuity, immune failure, mental defect. 

In humans, disease are frequently symptoms such as pain, stress, mental or physical disorder, social problems or death to the person suffered or similar problems suffered by near-by person in case, the disease is communicable. In the widest sense, it includes superficial damage, disabilities, disorder, syndromes, infections, isolated symptoms, behaviors & attitude.

Diseases may vary affect the people mentally, physically or may for life-time lasting. Death caused by disease is called natural death. The more sickness is feel in disease such as depression,  neuropsychiatric, anxiety and bipolar-disorder as well.

   

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