Tri-transgenic models

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Tri-transgenic mouse models represent of greater than two genes. Multiple mixtures and genetic changes are made in the sort of way that both one or all of the genes are positioned into a constantly expressed fame, or in a managed fashion to activate them at exceptional time points. For example, TOM( TetO-myc); TOR; MTB mice, wherein both the myc (M) and ras (R) genes are under the control of tetracycline operators. They also can each be activated or deactivated by using including doxycycline. Other combinations in this appreciate are TOM; Kras; MTB, wherein myc may be triggered and uninduced at various time factors while Kras is in continuous expressed kingdom, and myc; TOR; MTB model is vice versa.