Identification of genes that regulate metastasis

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By knocking in/knocking out unique genes by means of homologous recombination, the quantity of metastasis can be measured and new target genes identity may be finished e.G. A gene that continuously regulates metastatic behavior of cancer cells is TGF-β1. Acute ablation of TGF-β signaling in MMTV-PyMT mammary tumor cells leads to a 5-fold growth in lung metastasis. Certain enhancer regions also can be analyzed and may be decided to be a vital part of mobile proliferation e.G. An improving region that is associated with a most cancers vital gene p53 which become decided through CRISPR-Cas9.