Mouse mammary tumor virus (MMTV)-HER2/neu

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The Mouse mammary tumor virus (MMTV)-LTR also can be used to sell receptor tyrosine-protein kinase ErbB2 to convert the mouse mammary epithelium. ErbB2 is an oncogene amplified and overexpressed in around 20% of human breast cancers. The mice harbouring this oncogene broaden multifocal adenocarcinomas with lung metastases at about 15 weeks after being pregnant. To create a more accurate illustration of HER2 gene mutations, researchers have fused the mouse gene containing neu and a rat gene containing neu. This addresses the problem in terms of modeling the amplification of HER2 in mice development. In the non-fused mouse, the mammary gland would revert to a close to virgin, however with this addition the mammary gland maintained the evolved function.