Ependymomas are composed of cells with normal, spherical to oval nuclei. There is a variably dense fibrillary background. Tumor cells may additionally shape gland-like spherical or elongated systems that resemble the embryologic ependymal canal, with long, sensitive processes extending into the lumen; more regularly present are perivascular pseudorosettes wherein tumor cells are arranged around vessels with an intervening zone consisting of skinny ependymal strategies directed towards the wall of the vessel.
It has been suggested that ependymomas are derived from radial glia, despite their name suggesting an ependymal beginning.
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