Ion channels of Glioblastoma

Image Source-Google | Image by- | pharmakondotme.wordpress

Furthermore, GBM reveals numerous alterations in genes that encode for ion channels, such as upregulation of gBK potassium channels and ClC-3 chloride channels. By upregulating these ion channels, glioblastoma tumor cells are hypothesized to facilitate multiplied ion motion over the mobile membrane, thereby increasing H2O motion through osmosis, which aids glioblastoma cells in converting cell quantity very hastily. This is beneficial in their extremely aggressive invasive conduct because short adaptations in cellular extent can facilitate movement thru the sinuous extracellular matrix of the brain.