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Medulloblastomas are normally found inside the area of the fourth ventricle, among the brainstem and the cerebellum. Tumors with similar appearance and characteristics originate in different parts of the brain, but they are not equal to medulloblastoma.
Although medulloblastomas are notion to originate from immature or embryonal cells at their earliest degree of improvement, the mobile of origin depends on the subgroup of medulloblastoma. WNT tumors originate from the lower rhombic lip of the brainstem, even as SHH tumors originate from the outside granular layer.
Currently, medulloblastomas are notion to rise up from cerebellar stem cells which have been avoided from dividing and differentiating into their everyday cellular types. This accounts for the histologic versions seen on biopsy. Both perivascular pseudorosette and Homer Wright pseudorosette formations are particularly feature of medulloblastomas and are seen in up to 1/2 of cases. The traditional rosette with tumor cells around a primary lumen can be seen.
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