Symptomatic therapy of Glioblastoma

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Supportive remedy specializes in relieving symptoms and enhancing the affected person’s neurologic function. The primary supportive agents are anticonvulsants and corticosteroids.

Historically, around 90% of sufferers with glioblastoma underwent anticonvulsant remedy, although most effective an anticipated 40% of patients required this treatment. Recently, neurosurgeons were endorsed that anticonvulsants not be administered prophylactically, and need to wait till a seizure takes place before prescribing this medication. Those receiving phenytoin concurrent with radiation can also have severe skin reactions together with erythema multiforme and Stevens–Johnson syndrome.

Corticosteroids, typically dexamethasone, can reduce peritumoral edema (via rearrangement of the blood–mind barrier), diminishing mass impact and reducing intracranial strain, with a lower in headache or drowsiness.