Histopathological grading of Oligodendroglioma

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The histopathologic grading of oligodendrogliomas is debatable. Currently, the most usually used grading schema is primarily based at the yr 2007 World Health Organization (WHO) suggestions. An up to date classification is in progress. Oligodendrogliomas are typically dichotomized into grade II (low grade) tumor.
Unfortunately, the WHO guidelines include subjective criteria in grade II. In addition, the presence of low mitotic interest, vascular proliferation and necrosis, along with pseudopallisading necrosis, is insufficient with the aid of itself to raise the grade of this tumor. This results in inevitable interobserver variability in prognosis by means of pathologists. The final responsibility for making remedy decisions and interpretation of this analysis lies with the oncologist in consultation with the patient and their family.
It has been proposed that WHO suggestions ought to incorporate a category for grade IV oligodendrogliomas which basically appear like glial neoplasms with overwhelming features of glioblastoma multiforme (GBM) bobbing up from acknowledged lower grade oligodendrogliomas or GBM with a sizeable proportion of oligodendroglial differentiation. The diagnostic software of this latter class is uncertain as these tumors may additionally behave both like glioblastoma or grade III Anaplastic oligodendrogliomas. As such,that is a really unusual prognosis.
The up to date WHO hints posted in 2007 recommends classifying such tumors at the moment as 'glioblastoma with oligodendroglioma component'. It stays to be mounted whether or no longer those tumors convey a higher diagnosis than trendy glioblastomas.