Genetics of Primitive neuroectodermal tumor (PNET)

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Using gene switch of SV40 big T-antigen in neuronal precursor cells of rats, a mind tumor version turned into installed. The PNETs have been histologically indistinguishable from the human counterparts and have been used to perceive new genes involved in human brain tumor carcinogenesis. The model changed into used to verify p53 as one of the genes involved in human medulloblastomas, however in view that handiest approximately 10% of the human tumors showed mutations in that gene, the version may be used to perceive the opposite binding companions of SV40 Large T- antigen, aside from p53.